Pronol

Pronol may be available in the countries listed below.

Ingredient matches for Pronol

Naproxen

Naproxen sodium salt (a derivative of Naproxen) is reported as an ingredient of Pronol in the following countries:

• Ecuador

International Drug Name Search

penicillin Oral, Injection, Intravenous, Intramuscular

Commonly used brand name(s)

In the U.S.

• Amoxil


• Bactocill


• Bicillin L-A


• Cloxapen


• Crysticillin


• Dynapen


• Geocillin


• Nafcil


• Pfizerpen


• Pipracil


• Principen


• Staphcillin


• Ticar


• Veetids

In Canada

• Amoxil Pediatric


• Ampicillin Sodium


• Apo-Amoxi


• Apo-Amoxi Sugar-Free


• Apo-Cloxi


• Apo-Pen-Vk


• Gen-Amoxicillin


• Med Amoxicillin


• Nadopen V 200


• Nadopen V 400


• Novamoxin

Available Dosage Forms:

• Powder for Suspension


• Tablet


• Tablet, Chewable


• Tablet for Suspension


• Tablet, Extended Release


• Capsule


• Powder for Solution


• Suspension


• Solution


• Syrup

Uses For penicillin

Penicillins are used to treat infections caused by bacteria. They work by killing the bacteria or preventing their growth.

There are several different kinds of penicillins. Each is used to treat different kinds of infections. One kind of penicillin usually may not be used in place of another. In addition, penicillins are used to treat bacterial infections in many different parts of the body. They are sometimes given with other antibacterial medicines (antibiotics). Some of the penicillins may also be used for other problems as determined by your doctor. However, none of the penicillins will work for colds, flu, or other virus infections.

Penicillins are available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, penicillins are used in certain patients with the following medical conditions:

• Chlamydia infections in pregnant women—Amoxicillin and ampicillin


• Gas gangrene—Penicillin G


• Helicobacter pylori-associated gastritis or peptic ulcer disease—Amoxicillin


• Leptospirosis—Ampicillin and penicillin G


• Lyme disease—Amoxicillin and penicillin V


• Typhoid fever—Amoxicillin and ampicillin

Before Using penicillin

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Many penicillins have been used in children and, in effective doses, are not expected to cause different side effects or problems in children than they do in adults.

Some strengths of the chewable tablets of amoxicillin contain aspartame, which is changed by the body to phenylalanine, a substance that is harmful to patients with phenylketonuria.

Geriatric

Penicillins have been used in the elderly and have not been shown to cause different side effects or problems in older people than they do in younger adults.

Pregnancy

Penicillins have not been studied in pregnant women. However, penicillins have been widely used in pregnant women and have not been shown to cause birth defects or other problems in animal studies.

Breast Feeding

Penicillins pass into the breast milk. Even though only small amounts may pass into breast milk, allergic reactions, diarrhea, fungus infections, and skin rash may occur in nursing babies.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Cyclosporine


• Methotrexate


• Vecuronium


• Venlafaxine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

• Allergy, general (such as asthma, eczema, hay fever, hives), history of—Patients with a history of general allergies may be more likely to have a severe reaction to penicillins

• Bleeding problems, history of—Patients with a history of bleeding problems may be more likely to have bleeding when receiving carbenicillin, piperacillin, or ticarcillin

• Congestive heart failure (CHF) or


• High blood pressure—Large doses of carbenicillin or ticarcillin may make these conditions worse, because these medicines contain a large amount of salt

• Cystic fibrosis—Patients with cystic fibrosis may have an increased chance of fever and skin rash when receiving piperacillin

• Kidney disease—Patients with kidney disease may have an increased chance of side effects

• Mononucleosis (”mono”)—Patients with mononucleosis may have an increased chance of skin rash when receiving ampicillin, bacampicillin, or pivampicillin

• Phenylketonuria—Some strengths of the amoxicillin chewable tablets contain aspartame, which is changed by the body to phenylalanine, a substance that is harmful to patients with phenylketonuria.

• Stomach or intestinal disease, history of (especially colitis, including colitis caused by antibiotics)—Patients with a history of stomach or intestinal disease may be more likely to develop colitis while taking penicillins

Proper Use of penicillin

Penicillins (except bacampicillin tablets, amoxicillin, penicillin V, pivampicillin, and pivmecillinam) are best taken with a full glass (8 ounces) of water on an empty stomach (either 1 hour before or 2 hours after meals) unless otherwise directed by your doctor.

For patients taking amoxicillin, penicillin V, pivampicillin, and pivmecillinam:

• Amoxicillin, penicillin V, pivampicillin, and pivmecillinam may be taken on a full or empty stomach.


• The liquid form of amoxicillin may also be taken by itself or mixed with formulas, milk, fruit juice, water, ginger ale, or other cold drinks. If mixed with other liquids, take immediately after mixing. Be sure to drink all the liquid to get the full dose of medicine.

For patients taking bacampicillin:

• The liquid form of penicillin is best taken with a full glass (8 ounces) of water on an empty stomach (either 1 hour before or 2 hours after meals) unless otherwise directed by your doctor.


• The tablet form of penicillin may be taken on a full or empty stomach.

For patients taking penicillin G by mouth:

• Do not drink acidic fruit juices (for example, orange or grapefruit juice) or other acidic beverages within 1 hour of taking penicillin G since this may keep the medicine from working properly.

For patients taking the oral liquid form of penicillins:

• penicillin is to be taken by mouth even if it comes in a dropper bottle. If penicillin does not come in a dropper bottle, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.


• Do not use after the expiration date on the label. The medicine may not work properly after that date. If you have any questions about this, check with your pharmacist.

For patients taking the chewable tablet form of amoxicillin:

• Tablets should be chewed or crushed before they are swallowed.

To help clear up your infection completely, keep taking penicillin for the full time of treatment, even if you begin to feel better after a few days. If you have a ”strep” infection, you should keep taking penicillin for at least 10 days. This is especially important in ”strep” infections. Serious heart problems could develop later if your infection is not cleared up completely. Also, if you stop taking penicillin too soon, your symptoms may return.

penicillin works best when there is a constant amount in the blood or urine. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night . For example, if you are to take four doses a day, the doses should be spaced about 6 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.

Make certain your health care professional knows if you are on a low-sodium (low-salt) diet. Some of these medicines contain enough sodium to cause problems in some people.

Dosing

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

The number of tablets or teaspoonfuls of suspension that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking a penicillin.

• For amoxicillin:
  
  • For bacterial infections:
    
    • For oral dosage forms (capsules, oral suspension, tablets, and chewable tablets):
      
      • Adults, teenagers, and children weighing more than 40 kilograms (kg) (88 pounds)—250 to 500 milligrams (mg) every eight hours or 500 to 875 mg every twelve hours, depending on the type and severity of the infection.
      
      
      • Neonates and infants up to 3 months of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 15 mg per kg (6.8 mg per pound) of body weight or less every twelve hours.
      
      
      • Infants 3 months of age and older and children weighing up to 40 kg (88 lbs.)—Dose is based on body weight and must be determined by your doctor. The usual dose is 6.7 to 13.3 mg per kg (3 to 6 mg per pound) of body weight every eight hours or 12.5 to 22.5 mg per kg (5.7 to 10.2 mg per pound) of body weight every twelve hours.
        
        • For duodenal ulcers (associated with Helicobacter pylori bacterial infection):
          
          • For oral dosage forms (capsules, oral suspension, tablets, and chewable tablets):
            
            • Adults: 1000 mg twice a day every twelve hours for fourteen days, along with the two other medicines, clarithromycin and lansoprazole, as directed by your doctor.
            
            
            • Teenagers and children: Use and dose must be determined by your doctor.
              
              • For dual medicine therapy—
                
                • Adults: 1000 mg three times a day every eight hours for fourteen days, along with the other medicine, lansoprazole, as directed by your doctor.
                
                
                • Teenagers and children: Use and dose must be determined by your doctor.
                
                
              
              
            
            
          
          
        
        
      
      
    
    
  
  

• For ampicillin:
  
  • For bacterial infections:
    
    • For oral dosage forms (capsules and oral suspension):
      
      • Adults, teenagers, and children weighing more than 20 kilograms (kg) (44 pounds)—250 to 500 milligrams (mg) every six hours.
      
      
      • Infants and children weighing up to 20 kg (44 pounds)—Dose is based on body weight and must be determined by your doctor. The usual dose is 12.5 to 25 mg per kg (5.7 to 11.4 mg per pound) of body weight every six hours; or 16.7 to 33.3 mg per kg (7.6 to 15 mg per pound) of body weight every eight hours.
        
        • For injection dosage form:
          
          • Adults, teenagers, and children weighing more than 20 kg (44 pounds)—250 to 500 mg, injected into a vein or muscle every three to six hours.
          
          
          • Infants and children weighing up to 20 kg (44 pounds)—Dose is based on body weight and must be determined by your doctor. The usual dose is 12.5 mg per kg (5.7 mg per pound) of body weight, injected into a vein or muscle every six hours.
          
          
        
        
      
      
    
    
  
  

• For bacampicillin:
  
  • For bacterial infections:
    
    • For oral dosage forms (oral suspension and tablets):
      
      • Adults, teenagers, and children weighing more than 25 kilograms (kg) (55 pounds)—400 to 800 milligrams (mg) every twelve hours.
      
      
      • Children weighing up to 25 kg (55 pounds)—Bacampicillin tablets are not recommended for use in children weighing up to 25 kg (55 pounds). The dose of the oral suspension is based on body weight and must be determined by your doctor. The usual dose is 12.5 to 25 mg per kg (5.7 to 11.4 mg per pound) of body weight every twelve hours.
      
      
    
    
  
  

• For carbenicillin:
  
  • For bacterial infections:
    
    • For oral dosage form (tablets):
      
      • Adults and teenagers—500 milligrams (mg) to 1 gram every six hours.
      
      
      • Children—Dose must be determined by your doctor.
        
        • For injection dosage form:
          
          • Adults and teenagers—Dose is based on body weight and must be determined by your doctor. The usual dose is 50 to 83.3 mg per kilogram (kg) (22.8 to 37.9 mg per pound) of body weight, injected into a vein or muscle every four hours.
          
          
          • Older infants and children—Dose is based on body weight and must be determined by your doctor. The usual dose is 16.7 to 75 mg per kg (7.6 to 34 mg per pound) of body weight, injected into a vein or muscle every four to six hours.
          
          
        
        
      
      
    
    
  
  

• For cloxacillin:
  
  • For bacterial infections:
    
    • For oral dosage form (capsules and oral solution):
      
      • Adults, teenagers, and children weighing more than 20 kilograms (kg) (44 pounds)—250 to 500 milligrams (mg) every six hours.
      
      
      • Infants and children weighing up to 20 kg (44 pounds)—Dose is based on body weight and must be determined by your doctor. The usual dose is 6.25 to 12.5 mg per kg (2.8 to 5.7 mg per pound) of body weight every six hours.
        
        • For injection dosage form:
          
          • Adults, teenagers, and children weighing more than 20 kg—250 to 500 mg, injected into a vein every six hours.
          
          
          • Infants and children weighing up to 20 kg (44 pounds)—Dose is based on body weight and must be determined by your doctor. The usual dose is 6.25 to 12.5 mg per kg (2.8 to 5.7 mg per pound) of body weight, injected into a vein every six hours.
          
          
        
        
      
      
    
    
  
  

• For dicloxacillin:
  
  • For bacterial infections:
    
    • For oral dosage form (capsules and oral suspension):
      
      • Adults, teenagers, and children weighing more than 40 kilograms (kg) (88 pounds)—125 to 250 milligrams (mg) every six hours.
      
      
      • Infants and children weighing up to 40 kg (88 pounds)—Dose is based on body weight and must be determined by your doctor. The usual dose is 3.1 to 6.2 mg per kg (1.4 to 2.8 mg per pound) of body weight every six hours.
      
      
    
    
  
  

• For flucloxacillin:
  
  • For bacterial infections:
    
    • For oral dosage form (capsules and oral suspension):
      
      • Adults, teenagers, and children more than 12 years of age and weighing more than 40 kilograms (kg) (88 pounds)—250 to 500 milligrams (mg) every six hours.
      
      
      • Children less than 12 years of age and weighing up to 40 kg (88 pounds)—125 to 250 mg every six hours; or 6.25 to 12.5 mg per kg (2.8 to 5.7 mg per pound) of body weight every six hours.
      
      
      • Infants up to 6 months of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 6.25 mg per kg (2.8 mg per pound) of body weight every six hours.
      
      
    
    
  
  

• For methicillin:
  
  • For bacterial infections:
    
    • For injection dosage form:
      
      • Adults, teenagers, and children weighing more than 40 kilograms (kg) (88 pounds)—1 gram injected into a muscle every four to six hours; or 1 gram injected into a vein every six hours.
      
      
      • Children weighing up to 40 kg (88 pounds)—Dose is based on body weight and must be determined by your doctor. The usual dose is 25 milligrams (mg) per kg (11.4 mg per pound) of body weight, injected into a vein or muscle every six hours.
      
      
    
    
  
  

• For mezlocillin:
  
  • For bacterial infections:
    
    • For injection dosage form:
      
      • Adults and teenagers—Dose is based on body weight and must be determined by your doctor. The usual dose is 33.3 to 87.5 milligrams (mg) per kilogram (kg) (15.1 to 39.8 mg per pound) of body weight, injected into a vein or muscle every four to six hours; or 3 to 4 grams every four to six hours.
      
      
      • Infants over 1 month of age and children up to 12 years of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 50 mg per kg (22.7 mg per pound) of body weight, injected into a vein or muscle every four hours.
      
      
    
    
  
  

• For nafcillin:
  
  • For bacterial infections:
    
    • For oral dosage form (capsules and tablets):
      
      • Adults and teenagers—250 milligrams (mg) to 1 gram every four to six hours.
      
      
      • Older infants and children—Dose is based on body weight and must be determined by your doctor. The usual dose is 6.25 to 12.5 mg per kilogram (kg) (2.8 to 5.7 mg per pound) of body weight every six hours.
      
      
      • Newborns—Dose is based on body weight and must be determined by your doctor. The usual dose is 10 mg per kg (4.5 mg per pound) of body weight every six to eight hours.
        
        • For injection dosage form:
          
          • Adults and teenagers—500 mg to 2 grams injected into a vein or muscle every four to six hours.
          
          
          • Infants and children—Dose is based on body weight and must be determined by your doctor. The usual dose is 10 to 25 mg per kg (4.5 to 11.4 mg per pound) of body weight, injected into a muscle every twelve hours; or 10 to 40 mg per kg (4.5 to 18.2 mg per pound) of body weight, injected into a vein every four to eight hours.
          
          
        
        
      
      
    
    
  
  

• For oxacillin:
  
  • For bacterial infections:
    
    • For oral dosage form (capsules and oral solution):
      
      • Adults, teenagers, and children weighing more than 40 kilograms (kg) (88 pounds)—500 milligrams (mg) to 1 gram every four to six hours.
      
      
      • Children weighing up to 40 kg (88 pounds)—Dose is based on body weight and must be determined by your doctor. The usual dose is 12.5 to 25 mg per kg (5.7 to 11.4 mg per pound) of body weight every six hours.
        
        • For injection dosage form:
          
          • Adults, teenagers, and children weighing more than 40 kg (88 pounds)—250 mg to 1 gram injected into a vein or muscle every four to six hours.
          
          
          • Children weighing up to 40 kg (88 pounds)—Dose is based on body weight and must be determined by your doctor. The usual dose is 12.5 to 25 mg per kg (5.7 to 11.4 mg per pound) of body weight, injected into a vein or muscle every four to six hours.
          
          
          • Premature infants and newborns—Dose is based on body weight and must be determined by your doctor. The usual dose is 6.25 mg per kg (2.8 mg per pound) of body weight, injected into a vein or muscle every six hours.
          
          
        
        
      
      
    
    
  
  

• For penicillin G:
  
  • For bacterial infections:
    
    • For oral dosage form (oral solution, oral suspension, and tablets):
      
      • Adults and teenagers—200,000 to 500,000 Units (125 to 312 milligrams [mg]) every four to six hours.
      
      
      • Infants and children less than 12 years of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 4167 to 30,000 Units per kilogram (kg) (189 to 13,636 Units per pound) of body weight every four to eight hours.
        
        • For benzathine injection dosage form:
          
          • Adults and teenagers—1,200,000 to 2,400,000 Units injected into a muscle as a single dose.
          
          
          • Infants and children—300,000 to 1,200,000 Units injected into a muscle as a single dose; or 50,000 Units per kg (22,727 Units per pound) of body weight injected into a muscle as a single dose.
            
            • For injection dosage forms (potassium and sodium salts):
              
              • Adults and teenagers—1,000,000 to 5,000,000 Units, injected into a vein or muscle every four to six hours.
              
              
              • Older infants and children—Dose is based on body weight and must be determined by your doctor. The usual dose is 8333 to 25,000 Units per kg (3788 to 11,363 Units per pound) of body weight, injected into a vein or muscle every four to six hours.
              
              
              • Premature infants and newborns—Dose is based on body weight and must be determined by your doctor. The usual dose is 30,000 Units per kg (13,636 Units per pound) of body weight, injected into a vein or muscle every twelve hours.
                
                • For procaine injection dosage form:
                  
                  • Adults and teenagers—600,000 to 1,200,000 Units injected into a muscle once a day.
                  
                  
                  • Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 50,000 Units per kg (22,727 Units per pound) of body weight, injected into a muscle once a day.
                  
                  
                
                
              
              
            
            
          
          
        
        
      
      
    
    
  
  

• For penicillin V:
  
  • For bacterial infections:
    
    • For the benzathine salt oral dosage form (oral solution):
      
      • Adults and teenagers—200,000 to 500,000 Units every six to eight hours.
      
      
      • Children—100,000 to 250,000 Units every six to eight hours.
        
        • For the potassium salt oral dosage forms (oral solution, oral suspension, and tablets):
          
          • Adults and teenagers—125 to 500 milligrams (mg) every six to eight hours.
          
          
          • Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 2.5 to 16.7 mg per kilogram (kg) (1.1 to 7.6 mg per pound) of body weight every four to eight hours.
          
          
        
        
      
      
    
    
  
  

• For piperacillin:
  
  • For bacterial infections:
    
    • For injection dosage form:
      
      • Adults and teenagers—3 to 4 grams, injected into a vein or muscle every four to six hours.
      
      
      • Infants and children—Dose must be determined by your doctor.
      
      
    
    
  
  

• For pivampicillin:
  
  • For bacterial infections:
    
    • For oral dosage form (oral suspension):
      
      • Adults, teenagers, and children 10 years of age and older—525 to 1050 milligrams (mg) two times a day.
      
      
      • Children 7 to 10 years of age—350 mg two times a day.
      
      
      • Children 4 to 6 years of age—262.5 mg two times a day.
      
      
      • Children 1 to 3 years of age—175 mg two times a day.
      
      
      • Infants 3 to 12 months of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 20 to 30 mg per kilogram (kg) (9.1 to 13.6 mg per pound) of body weight two times a day.
        
        • For oral dosage form (tablets):
          
          • Adults, teenagers, and children 10 years of age and older—500 mg to 1 gram two times a day.
          
          
          • Children up to 10 years of age—Dose must be determined by your doctor.
          
          
        
        
      
      
    
    
  
  

• For pivmecillinam:
  
  • For bacterial infections:
    
    • For oral dosage form (tablets):
      
      • Adults, teenagers, and children weighing more than 40 kilograms (kg) (88 pounds)—200 milligrams (mg) two to four times a day for three days.
      
      
      • Children up to 40 kg (88 pounds)—Dose must be determined by your doctor.
      
      
    
    
  
  

• For ticarcillin:
  
  • For bacterial infections:
    
    • For injection dosage form:
      
      • Adults, teenagers, and children weighing more than 40 kilograms (kg) (88 pounds)—3 grams injected into a vein every four hours; or 4 grams injected into a vein every six hours.
      
      
      • Children up to 40 kg (88 pounds)—Dose is based on body weight and must be determined by your doctor. The usual dose is 33.3 to 75 milligrams (mg) per kg (15 to 34 mg per pound) of body weight, injected into a vein every four to six hours.
      
      
    
    
  
  

Missed Dose

If you miss a dose of penicillin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using penicillin

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

Penicillins may cause diarrhea in some patients.

• Check with your doctor if severe diarrhea occurs. Severe diarrhea may be a sign of a serious side effect. Do not take any diarrhea medicine without first checking with your doctor. Diarrhea medicines may make your diarrhea worse or make it last longer.


• For mild diarrhea, diarrhea medicine containing kaolin or attapulgite (e.g., Kaopectate tablets, Diasorb) may be taken. However, other kinds of diarrhea medicine should not be taken. They may make your diarrhea worse or make it last longer.


• If you have any questions about this or if mild diarrhea continues or gets worse, check with your health care professional.

Oral contraceptives (birth control pills) containing estrogen may not work properly if you take them while you are taking ampicillin, amoxicillin, or penicillin V. Unplanned pregnancies may occur. You should use a different or additional means of birth control while you are taking any of these penicillins. If you have any questions about this, check with your health care professional.

For diabetic patients:

• Penicillins may cause false test results with some urine sugar tests. Check with your doctor before changing your diet or the dosage of your diabetes medicine.

Before you have any medical tests, tell the doctor in charge that you are taking penicillin. The results of some tests may be affected by penicillin.

penicillin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking penicillin and get emergency help immediately if any of the following effects occur:

Less common

• Fast or irregular breathing


• fever


• joint pain


• lightheadedness or fainting (sudden)


• puffiness or swelling around the face


• red, scaly skin


• shortness of breath


• skin rash, hives, itching

Check with your doctor immediately if any of the following side effects occur:

Rare

• Abdominal or stomach cramps and pain (severe)


• abdominal tenderness


• convulsions (seizures)


• decreased amount of urine


• diarrhea (watery and severe), which may also be bloody


• mental depression


• nausea and vomiting


• pain at place of injection


• sore throat and fever


• unusual bleeding or bruising


• yellow eyes or skin

Rare - For penicillin G procaine only

• Agitation or combativeness


• anxiety


• confusion


• fear of impending death


• feeling, hearing, or seeing things that are not real

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Diarrhea (mild)


• headache


• sore mouth or tongue


• vaginal itching and discharge


• white patches in the mouth and/or on the tongue

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: penicillin Oral, Injection, Intravenous, Intramuscular side effects (in more detail)

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• Aspiration Pneumonia
• Bacterial Infection
• Clostridial Infection
• Congenital Syphilis
• Cutaneous Bacillus anthracis
• Deep Neck Infection
• Diphtheria
• Endocarditis
• Fusospirochetosis, Trench Mouth
• Joint Infection
• Leptospirosis
• Lyme Disease, Arthritis
• Lyme Disease, Carditis
• Lyme Disease, Erythema Chronicum Migrans
• Lyme Disease, Neurologic
• Meningitis
• Meningitis, Meningococcal
• Meningitis, Pneumococcal
• Neurosyphilis
• Otitis Media
• Pneumonia
• Prevention of Perinatal Group B Streptococcal Disease
• Rat-bite Fever
• Rheumatic Fever Prophylaxis
• Skin Infection
• Strep Throat
• Syphilis, Early
• Syphilis, Latent
• Tertiary Syphilis
• Tonsillitis/Pharyngitis
• Upper Respiratory Tract Infection

Skelaxin

Pronunciation: me-TAX-a-lone
Generic Name: Metaxalone
Brand Name: Skelaxin

Skelaxin is used for:

Treating discomfort associated with acute painful muscle conditions along with rest, physical therapy, or other measures.

Skelaxin is a muscle relaxant. It works in the brain to help relax the muscles.

Do NOT use Skelaxin if:

• you are allergic to any ingredient in Skelaxin


• you have a known tendency to drug-induced, hemolytic, or other anemias


• you have severe liver or kidney problems


• you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Skelaxin:

Some medical conditions may interact with Skelaxin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have an enlarged prostate gland, liver or kidney problems, or the blood disease porphyria

Some MEDICINES MAY INTERACT with Skelaxin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Benzodiazepines (eg, diazepam), narcotic pain medicines (eg, codeine), or tricyclic antidepressants (eg, amitriptyline) because the risk of drowsiness may be increased


• Sodium oxybate (GHB) because an increase in sleep duration and a decrease in the ability to breathe are likely to occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Skelaxin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Skelaxin:

Use Skelaxin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Skelaxin by mouth with or without food. Taking it with food may increase the risk of drowsiness or dizziness.


• If you miss a dose of Skelaxin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Skelaxin.

Important safety information:

• Skelaxin may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Skelaxin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Talk with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Skelaxin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Diabetes patients - Skelaxin may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.


• Lab tests, including liver function, may be performed while you use Skelaxin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Skelaxin with caution in the ELDERLY; they may be more sensitive to its effects, especially drowsiness or dizziness.


• Skelaxin should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Skelaxin while you are pregnant. It is not known if Skelaxin is found in breast milk. Do not breast-feed while taking Skelaxin.

Possible side effects of Skelaxin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; headache; irritability; nausea; nervousness; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fever, chills, or sore throat; unusual or severe tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Skelaxin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Skelaxin:

Store Skelaxin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Skelaxin out of the reach of children and away from pets.

General information:

• If you have any questions about Skelaxin, please talk with your doctor, pharmacist, or other health care provider.


• Skelaxin is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Skelaxin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Skelaxin resources

• Skelaxin Side Effects (in more detail)
• Skelaxin Use in Pregnancy & Breastfeeding
• Drug Images
• Skelaxin Drug Interactions
• Skelaxin Support Group
• 51 Reviews for Skelaxin - Add your own review/rating

• Skelaxin Prescribing Information (FDA)


• Skelaxin Consumer Overview


• Skelaxin Monograph (AHFS DI)


• Skelaxin Advanced Consumer (Micromedex) - Includes Dosage Information


• Metaxalone Prescribing Information (FDA)


• Metaxalone Professional Patient Advice (Wolters Kluwer)

Compare Skelaxin with other medications

• Fibromyalgia
• Muscle Spasm

Bricasma

Bricasma may be available in the countries listed below.

Ingredient matches for Bricasma

Terbutaline

Terbutaline sulfate (a derivative of Terbutaline) is reported as an ingredient of Bricasma in the following countries:

• Indonesia

International Drug Name Search

Hishidarin

Hishidarin may be available in the countries listed below.

Ingredient matches for Hishidarin

Protirelin

Protirelin tartrate (a derivative of Protirelin) is reported as an ingredient of Hishidarin in the following countries:

• Japan

International Drug Name Search

Flexin

Flexin may be available in the countries listed below.

Ingredient matches for Flexin

Cyclobenzaprine

Cyclobenzaprine hydrochloride (a derivative of Cyclobenzaprine) is reported as an ingredient of Flexin in the following countries:

• Chile

Diclofenac

Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of Flexin in the following countries:

• Argentina

Orphenadrine

Orphenadrine citrate (a derivative of Orphenadrine) is reported as an ingredient of Flexin in the following countries:

• Israel

International Drug Name Search

Tranylcypromine

In the US, Tranylcypromine (tranylcypromine systemic) is a member of the drug class monoamine oxidase inhibitors and is used to treat Depression.

US matches:

• Tranylcypromine


• Tranylcypromine Sulfate

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

N06AF04

CAS registry number (Chemical Abstracts Service)

0000155-09-9

Chemical Formula

C9-H11-N

Molecular Weight

133

Therapeutic Category

Antidepressant: Inhibitor of monoamine oxidase type A (MAO-A)

Chemical Name

Cyclopropanamine, 2-phenyl-, trans-(±)-

Foreign Names

• Tranylcyprominum (Latin)
• Tranylcypromin (German)
• Tranylcypromine (French)
• Tranilcipromina (Spanish)

Generic Names

• Tranilcipromina (OS: DCIT)
• Tranylcypromine (OS: DCF, BAN)
• Tranylcypromine Sulphate (OS: BANM)
• Tranylcypromin hemisulfat (IS)
• Tranylcypromine Sulfate (PH: USP XXI)
• Tranylcypromine Sulphate (PH: BP 2010)

Brand Names

• Parnate
  GlaxoSmithKline, Brazil; Pharmafrica, South Africa



• Jatrosom
  Esparma, Germany



• Parmodalin (Tranylcypromine and Trifluoperazine)
  SIT, Italy



• Parnate
  GlaxoSmithKline, United Arab Emirates; GlaxoSmithKline, Bahrain; GlaxoSmithKline, Canada; GlaxoSmithKline, Iran; GlaxoSmithKline, Kuwait; GlaxoSmithKline, Oman; GlaxoSmithKline, Qatar; GlaxoSmithKline, United States; Goldshield, Australia; Goldshield, Spain; Goldshield, Ireland; Goldshield, New Zealand



• Tranylcypromine
  Kali, United States

International Drug Name Search

Glossary

BAN	British Approved Name
BANM	British Approved Name (Modified)
DCF	Dénomination Commune Française
DCIT	Denominazione Comune Italiana
IS	Inofficial Synonym
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.

Canimax

Canimax may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Canimax

Abamectin

Abamectin is reported as an ingredient of Canimax in the following countries:

• Australia

Oxibendazole

Oxibendazole is reported as an ingredient of Canimax in the following countries:

• Australia

Praziquantel

Praziquantel is reported as an ingredient of Canimax in the following countries:

• Australia

International Drug Name Search

Pennchlor 64

Generic Name: chlortetrcycline hydrochloride powder

Dosage Form: FOR ANIMAL USE ONLY

Pennchlor 64 - Chlortetracycline hydrochloride - 102.4 g per packets (64g/lb)


RESIDUE WARNINGS


Do not administer to chickens within 24 hours of slaughter.  Do not use in laying chickens.  Do not administer to growing turkeys within 24 hours of slaughter.  Zero day withdrawal in swine.  Do not administer to cattle within 24 hours of slaughter.  Do not use in lactating dairy cattle.  A withdrawal period has not been established in pre-ruminating calves.  Do not use in calves to be processed for veal.

General Information on Dosage

Dosages in terms of packets per 512 gallons are based on stated dosages per unit of body weight and average water consumption of the species.  Weather conditions, ambient temperature, humidity, age, class of livestock and other factors may affect consumption and, except where calves are drenched, the unit dosage should be used as a guide to effective use in drinking water.  Animals must actually consume enough medicated water to provide the desired therapeutic dose under the conditions that prevail.

PRECAUTIONS


Use as the sole source of chlortetracycline.  Prepare fresh solutions daily.  When used in plastic or stainless steel waterers or automatic waterers, prepare fresh solutions every 24 hours.  When used in galvanized waterers, prepare fresh solutions every 12 hours.  Do not administer in milk or milk replacers.  When feeding milk or milk replacers, administration one hour before or two hours after feeding is recommended.

INDICATIONS


CHICKENS

Control of infectious synovitis caused by Mycoplasma synoviae susceptible to chlortetracycline.


Control of Chronic Respiratory Disease (CRD) and air-sac infections caused by Mycoplasma gallisepticum and Escherichia coli susceptible to chlortetracycline.


Control of mortality due to fowl cholera caused by Pasteurella multocida susceptible to chlortetracycline.

DIRECTIONS FOR USE


DOSE

200-400 mg/gal (1-2 packets/512 gallons, this is equivalent to 2-4 teaspoons of powder per 5 gallons of water), administer at the indicated rates in the total water consumed over a full, 24-hour period.  Administer 7 to 14 days.


400-800 mg/gal (2-4 packets/512 gallons, this is equivalent to 4-8 teaspoons of powder per 5 gallons of water), administer at the indicated rates in the total water consumed over a full, 24-hour period.  Administer 7 to 14 days.


1000 mg/gal (5 packets/512 gallons, this is equivalent to 2 teaspoons of powder per 1 gallon of water), administer at the indicated rates in the total water consumed over a full, 24-hour period.  Administer 7 to 14 days.

INDICATIONS


SWINE


Control and treatment of bacterial enteritis (scours) caused by Escherichia coli and Samonella spp. and bacterial pneumonia associated with Pasteurella spp., Actinobacillus pleuropneumoniae, and Klebsiella spp. susceptible to chlortetracycline. DIRECTIONS FOR USE


DOSE - 10 mg/pound body weight daily


(5 packets/512 gallons will treat 512 100-lb pigs per day, 2 teaspoons of powder will treat a 100 lb. pig for one day).  Administer at this rate in the total water consumed over a full, 24-hour period.  Administer for 3-5 days.

DIRECTIONS FOR USE


DOSE - 10 mg/pound body weight daily

(5 packets/512 gallons will treat 512 100-lb pigs per day, 2 teaspoons of powder will treat a 100 lb. pig for one day).  Administer at this rate in the total water consumed over a full, 24-hour period.  Administer for 3-5 days.

INDICATIONS


CALVES, BEEF CATTLE, AND NON-LACTATING DAIRY CATTLE


Control and treatment of bacterial enteritis (scours) caused by Escherichia coli and Salmonella spp. and bacterial pneumonia associated with Pasteurella spp., Histophilus spp., and Klebsiella spp. susceptible to chlortetracycline.

DIRECTIONS FOR USE


DOSE - 10 mg/pound body weight daily

Use 2 teaspoon of powder for each 100 lbs. of calf weight per day.  Administer at this rate in the total water consumed over a full, 24-hour period, or as a drench in divided doses.  Administer 3 to 5 days.

INDICATIONS


GROWING TURKEYS


Control of infectious synovitis caused by Mycoplasma synoviae susceptible to chlortetracycline.


Control of complicating bacterial organisms associated with bluecomb (transmissible enteritis, coronaviral enteritis) susceptible to chlortetracycline.
DIRECTIONS FOR USE


DOSE


400 mg/gal (2 packets/512 gallons, this is equivalent to 4 teaspoons of powder per 5 gallons of water), administer at this rate in the total water consumed over a full, 24-hour period.  Administer 7 to 14 days.


25 mg/lb body weight/day (1 packet for every 4,096 lbs of turkeys, 1 teaspoon treats a 20 lb. turkey for one day), administer in the total water consumed over a full, 24-hour period.  Administer 7 to 14 days.



Medicate chickens and turkeys continuously at the first clinical signs of disease and continue for 7 to 14 consecutive days.  The dosage ranges permitted for different levels based on the severity of the infection.  If improvement is not noted in 24-48 hours, consult a veterinarian or a diagnostic laboratory to determine diagnoses and for advice regarding the optimal level of the drug where ranges are permitted.

Pennchlor 64

Chlortetracyline HCI


SOLUBLE POWDER CONCENTRATE


Antibiotic

For Animal Use in Drinking Water


Chlortetracycline hydrochloride 64 g per pound


Each packet contains 102.4 g of chlortetracycline HCI and will make:

    1,024 gallons (3,876 L) containing 100 mg Pennchlor 64 chlortetracycline HCI per gallon


    512 gallons (1,938 L) containing 200 mg Pennchlor 64 chlortetracycline HCI per gallon


    256 gallons (969 L) containing 400 mg Pennchlor 64 chlortetracycline HCI per gallon


    102.4 gallons (387 L) containing 1,000 mg Pennchlor 64 chlortetracycline HCI per gallon


        Each teaspoon of Pennchlor 64 powder contains 500 mg of chlortetracycline HCI


Net Contents:  25.6 oz (725.7 g)


ANADA 200-295  APPROVED BY FDA

RESTRICTED DRUG (CA): USE ONLY AS DIRECTED.

NOT FOR HUMAN USE

STORE AT CONTROLLED ROOM TEMPERATURE 15 degrees to 30 degrees C (59 degrees to 86 degrees F)

Pennchlor 64  chlortetrcycline hydrochloride  powder

Product Information Product Type OTC ANIMAL DRUG NDC Product Code (Source) 48164-0026 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Chlortetracycline Hydrochloride (Chlortetracycline ) Chlortetracycline Hydrochloride 141 g  in 1 kg

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 48164-0026-6 141 kg In 1 PACKET None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANADA	ANADA200295	04/27/2001

Labeler - PennField Oil Company (035138569)

Revised: 05/2010PennField Oil Company

Pentam

Pronunciation: pen-TAM-i-deen
Generic Name: Pentamidine
Brand Name: Pentam

Pentam is used for:

Treating Pneumocystis jiroveci pneumonia (PCP). It may also be used for other conditions as determined by your doctor.

Pentam is an antiprotozoal agent. Exactly how Pentam works in unknown.

Do NOT use Pentam if:

• you are allergic to any ingredient in Pentam


• you are taking cisapride, dofetilide, an H₁ antagonist (eg, astemizole, terfenadine), ibutilide, sparfloxacin, zalcitabine, or ziprasidone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pentam:

Some medical conditions may interact with Pentam. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have heart problems (eg, irregular heartbeat), high or low blood pressure, blood problems (eg, anemia, low levels of white blood cells or platelets), low level of calcium in the blood, or liver, kidney, or pancreas problems


• if you have diabetes or high or low blood sugar


• if you are dehydrated


• if you have a history of breathing or lung problems (eg, asthma), smoking, or PCP


• if you have a history of Stevens-Johnson syndrome (red, swollen, blistered, peeling skin)

Some MEDICINES MAY INTERACT with Pentam. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Arsenic, cisapride, dofetilide, H₁ antagonists (eg, astemizole, terfenadine), ibutilide, ketolides (eg, telithromycin), macrolides (eg, erythromycin), sparfloxacin, or ziprasidone because the risk of side effects such as irregular heartbeat may be increased


• Zalcitabine because the risk of pancreas side effects may be increased


• Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cisplatin, cyclosporine, foscarnet, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pentam may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pentam:

Use Pentam as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Pentam is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Pentam at home, carefully follow the injection procedures taught to you by your health care provider.


• Lie down while using Pentam because of the risk of severe dizziness.


• If Pentam contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.


• To clear up your infection completely, continue using Pentam for the full course of treatment even if you feel better in a few days.


• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.


• If you miss a dose of Pentam, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Pentam.

Important safety information:

• Pentam may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Pentam. Using Pentam alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Pentam may cause low blood sugar (eg, increased heartbeat, headache, chills, sweating, tremor, increased hunger, changes in vision, nervousness, weakness, dizziness, drowsiness, fainting) or high blood sugar (eg, thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, fruity breath odor). If these symptoms occur, tell your doctor immediately.


• LAB TESTS, including blood pressure, blood sugar levels, and complete blood counts, may be performed to monitor your progress or to check for side effects. Make sure you keep all doctor and laboratory appointments.


• Use Pentam with extreme caution in CHILDREN younger than 4 months of age. Safety and effectiveness in this age group have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is unknown if Pentam can cause harm to the fetus. If you become pregnant while taking Pentam, discuss with your doctor the benefits and risks of using Pentam during pregnancy. It is unknown if Pentam is excreted in breast milk. Do not breast-feed while you are using Pentam.

Possible side effects of Pentam:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bad taste in mouth; cough; decreased appetite; diarrhea; dizziness; headache; nausea; night sweats; sinus inflammation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; chest pain; dark urine; fast or irregular heartbeat; fever, chills, or sore throat; herpes infection (eg, shingles); increased or decreased urination; increased thirst; mental or mood changes; one-sided weakness; pain, swelling, or redness at the injection site; pounding in the chest; red, swollen, blistered, or peeling skin; seizures; severe or persistent dizziness, nausea, or cough; shortness of breath; slurred speech; stomach pain; unusual bruising or bleeding; unusual tiredness or weakness; wheezing; white patches in the mouth or throat; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Pentam side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; decreased urination; severe or persistent dizziness; yellowing of the skin or eyes.

Proper storage of Pentam:

Pentam is usually handled and stored by a health care provider. If you are using Pentam at home, store Pentam as directed by your pharmacist or health care provider. Keep Pentam out of the reach of children and away from pets.

General information:

• If you have any questions about Pentam, please talk with your doctor, pharmacist, or other health care provider.


• Pentam is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Pentam. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Pentam resources

• Pentam Side Effects (in more detail)
• Pentam Use in Pregnancy & Breastfeeding
• Pentam Drug Interactions
• Pentam Support Group
• 0 Reviews for Pentam - Add your own review/rating

Compare Pentam with other medications

• Leishmaniasis
• Pneumocystis Pneumonia
• Pneumocystis Pneumonia Prophylaxis
• Trypanosomiasis

Pazopanib

Pronunciation: paz-OH-pa-nib
Generic Name: Pazopanib
Brand Name: Votrient

Severe and sometimes fatal liver problems have occurred in patients using Pazopanib. Your doctor will monitor your liver function while you are using Pazopanib. Tell your doctor right away if you experience symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; severe or persistent stomach pain, nausea, or loss of appetite; severe or persistent tiredness).

Pazopanib is used for:

Treating patients with advanced kidney cancer.

Pazopanib is a tyrosine kinase inhibitor. It works by blocking certain substances in the body, which kills certain cancer cells.

Do NOT use Pazopanib if:

• you are allergic to any ingredient in Pazopanib


• you have severe liver problems


• you have had bleeding in the brain, bleeding in the stomach or bowels, or coughing up blood in the past 6 months


• you have had an angina attack, heart attack, stroke, or transient ischemic attack (TIA, "mini-stroke") in the past 6 months


• you have a surgical wound that has split apart


• you are taking barbiturates (eg, phenobarbital, primidone), carbamazepine, dexamethasone, halofantrine, hydantoins (eg, phenytoin), nevirapine, rifamycins (eg, rifampin), or St. John's wort

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pazopanib:

Some medical conditions may interact with Pazopanib. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have high blood pressure, irregular heartbeat (eg, QT prolongation) or other heart problems, abnormal electrolyte levels (eg, potassium, calcium, magnesium), thyroid problems, or a wound that has not fully healed


• if you have a history of stomach or bowel problems (eg, ulcer, tearing, fistula, bleeding) or blood clots (eg, in your legs or lungs), or you are at risk of developing these problems


• if you have a history of angina attacks, heart attack, stroke, or transient ischemic attack (TIA; "mini-stroke") or you are at risk of developing these problems


• if you have a history of liver problems, bleeding in the brain, or coughing up blood


• if you are or will be having surgery, or you have recently had surgery (eg, within the last 7 days)


• if you take medicine for depression

Some MEDICINES MAY INTERACT with Pazopanib. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Antiarrhythmics (eg, amiodarone, propafenone, sotalol), arsenic, astemizole, bepridil, chloroquine, cisapride, dolasetron, domperidone, droperidol, halofantrine, haloperidol, iloperidone, maprotiline, methadone, paliperidone, pentamidine, phenothiazines (eg, thioridazine), pimozide, quinolone antibiotics (eg, ciprofloxacin), romidepsin, tacrolimus, terfenadine, toremifene, tricyclic antidepressants (eg, amitriptyline), ziprasidone, or any other medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat


• Azole antifungals (eg, ketoconazole), macrolide antibiotics (eg, clarithromycin), nefazodone, or protease inhibitors (eg, boceprevir, ritonavir) because they may increase the risk of Pazopanib's side effects


• Barbiturates (eg, phenobarbital, primidone), carbamazepine, dexamethasone, hydantoins (eg, phenytoin), nevirapine, rifamycins (eg, rifampin), or St. John's wort because they may decrease Pazopanib's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pazopanib may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pazopanib:

Use Pazopanib as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Pazopanib comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Pazopanib refilled.


• Take Pazopanib by mouth on an empty stomach at least 1 hour before or 2 hours after eating.


• Swallow Pazopanib whole. Do not break, crush, or chew before swallowing.


• Do not eat grapefruit or drink grapefruit juice while you use Pazopanib.


• If you miss a dose of Pazopanib, take it as soon as possible. If there are less than 12 hours before your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pazopanib.

Important safety information:

• Do not take more than the recommended dose without checking with your doctor.


• Tell your doctor or dentist that you take Pazopanib before you receive any medical or dental care, emergency care, or surgery.


• Mild diarrhea is common with Pazopanib. Check with your doctor if moderate to severe diarrhea occurs.


• Women who may become pregnant should use effective birth control while they are taking Pazopanib. Check with your doctor if you have questions about effective birth control.


• Pazopanib may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.


• Severe and sometimes fatal bleeding has rarely occurred in patients taking Pazopanib. Contact your doctor right away if you develop blood in the urine, coughing or spitting up blood, severe or persistent nosebleed, or other unusual bruising or bleeding.


• Severe and sometimes fatal stomach or bowel problems (eg, tearing, fistula) have rarely occurred in patients taking Pazopanib. Contact your doctor right away if you develop severe or persistent stomach pain, black tarry or bloody stools, or vomiting blood or a substance that looks like coffee grounds.


• Tell your doctor if you have a wound that does not heal.


• Lab tests, including liver and thyroid function, urine protein levels, blood pressure, blood electrolytes, and heart function, may be performed while you use Pazopanib. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Pazopanib with caution in the ELDERLY; they may be more sensitive to its effects, especially liver problems.


• Pazopanib should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not use Pazopanib if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Pazopanib is found in breast milk. Do not breast-feed while you are taking Pazopanib.

Possible side effects of Pazopanib:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; hair loss; headache; indigestion; lightening of hair or skin color; loss of appetite; mild stomach pain; nausea; taste changes; tiredness; vomiting; weakness; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; blood in the urine; calf or leg pain, swelling, or tenderness; chest pain; coughing or spitting up blood; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; severe or persistent headache, dizziness, or stomach pain; severe or persistent nosebleed; shortness of breath; stomach swelling; symptoms of heart attack or stroke (eg, chest pain, confusion, numbness of an arm or leg, one-sided weakness, speech problems, sudden severe headache or vomiting, vision problems); symptoms of liver problems (eg, dark urine, loss of appetite, nausea, pale stools, severe or persistent stomach pain, severe or persistent tiredness, yellowing of the skin or eyes); tingling, pain, or tenderness of the palms of the hands or soles of the feet; unusual bruising or bleeding; vomiting blood or a substance that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Pazopanib side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe or persistent headache or tiredness.

Proper storage of Pazopanib:

Store Pazopanib between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pazopanib out of the reach of children and away from pets.

General information:

• If you have any questions about Pazopanib, please talk with your doctor, pharmacist, or other health care provider.


• Pazopanib is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Pazopanib. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Pazopanib resources

• Pazopanib Side Effects (in more detail)
• Pazopanib Use in Pregnancy & Breastfeeding
• Pazopanib Drug Interactions
• Pazopanib Support Group
• 7 Reviews for Pazopanib - Add your own review/rating

• Pazopanib Professional Patient Advice (Wolters Kluwer)


• pazopanib Advanced Consumer (Micromedex) - Includes Dosage Information


• Pazopanib Hydrochloride Monograph (AHFS DI)


• Votrient Prescribing Information (FDA)


• Votrient Consumer Overview

Compare Pazopanib with other medications

• Renal Cell Carcinoma

Nutropin AQ

Generic Name: somatropin (soe ma TROE pin)

Brand Names: Genotropin, Genotropin Miniquick, Humatrope, Norditropin, Norditropin Cartridge, Norditropin FlexPro Pen, Norditropin Nordiflex Pen, Nutropin, Nutropin AQ, Omnitrope, Saizen, Serostim, Tev-tropin, Zorbtive

What is Nutropin AQ (somatropin)?

Somatropin is a form of human growth hormone. Human growth hormone is important in the body for the growth of bones and muscles.

Somatropin is used to treat growth failure in children and adults who lack natural growth hormone, and in those with chronic kidney failure, Noonan syndrome, Turner syndrome, Prader-Willi syndrome, short stature at birth with no catch-up growth, and other causes. Somatropin is also used to prevent severe weight loss in people with AIDS, or to treat short bowel syndrome.

Somatropin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Nutropin AQ (somatropin)?

Before you receive somatropin, tell your doctor about all your past and present medical conditions, especially allergies, trauma, surgery, diabetes, cancer, breathing problems, liver or kidney disease, scoliosis, high blood pressure, pancreas disorder, underactive thyroid, or a brain tumor.

Also tell your doctor about all other medications you use, especially steroids or diabetes medications. Your dosages of these medicines may need to be changed when you start using somatropin. Do not stop using a steroid suddenly or change any of your medication doses without your doctor's advice.

If you have Prader-Willi syndrome and are using somatropin, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring.

Call your doctor at once if you have sudden and severe pain in your upper stomach with nausea and vomiting, fast heartbeat, increased thirst or urination, weight loss, or vision changes and sudden, severe pain behind your eyes.

What should I discuss with my healthcare provider before using Nutropin AQ (somatropin)?

Before you receive somatropin, tell your doctor if you have ever had an allergic reaction to a growth hormone medicine, or to drug preservatives such as benzyl alcohol, metacresol or glycerin. You should not use this medication if you are allergic to somatropin, or if you have:

• 
  

  diabetic retinopathy (a serious eye condition caused by diabetes);

  
  


• 
  

  cancer; or

  
  


• 
  

  Prader-Willi syndrome and are also overweight or have sleep apnea or severe respiratory (lung) problems.

  
  

You should also not use somatropin if you have a serious medical condition after having:

• 
  

  open heart surgery or stomach surgery;

  
  


• 
  

  trauma or other medical emergency; or

  
  


• 
  

  breathing problems (such as lung failure).

  
  

To make sure you can safely take somatropin, tell your doctor if you have any of these other conditions:

• 
  

  liver disease;

  
  


• 
  

  kidney disease (or if you are on dialysis);

  
  


• 
  

  diabetes;

  
  


• 
  

  a pituitary gland disorder;

  
  


• 
  

  scoliosis;

  
  


• 
  

  high blood pressure (hypertension);

  
  


• 
  

  a pancreas disorder (especially in children);

  
  


• 
  

  a history of cancer;

  
  


• 
  

  carpal tunnel syndrome;

  
  


• 
  

  underactive thyroid; or

  
  


• 
  

  a brain tumor or lesion.

  
  

FDA pregnancy category B. Some brands of somatropin are not expected to harm an unborn baby, including Genotropin, Omnitrope, Saizen, Serostim, and Zorbtive. FDA pregnancy category C. It is not known whether certain other brands of somatropin will harm an unborn baby, including Humatrope, Norditropin, Nutropin, and Tev-tropin. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether somatropin passes into breast milk or if it could harm a nursing baby. Do not use somatropin without telling your doctor if you are breast-feeding a baby.

How should I use Nutropin AQ (somatropin)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your dose and brand of somatropin, and how often you give it will depend on what you are being treated for. Follow the directions on your prescription label.

Somatropin is injected into a muscle or under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Use a different place on your body each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row. Do not inject this medicine into skin or muscle that is red, sore, infected, or injured.

Do not shake the medication bottle or you may ruin the medicine. When mixing somatropin with a diluent (liquid), use a gentle swirling motion. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

To be sure this medication is helping your condition and not causing harm, your blood and growth progress will need to be tested often. Your eyes may also need to be checked. Visit your doctor regularly.

If you are being treated for short bowel syndrome, follow the diet plan created for you by your doctor or nutrition counselor to help control your condition. Somatropin is not a cure for short bowel syndrome.

If you use a form of somatropin that comes in a cartridge for use with an injection pen, use only the pen injection system provided with the somatropin brand you use.

How you store this medicine will depend on what brand you are using and what diluent you are mixing somatropin with. After mixing somatropin, you may need to use it right away or you may be able to store it for later use. Read and carefully follow the instructions provided with your medicine about proper storage of somatropin before and after it has been mixed. Ask your pharmacist if you have any questions about proper storage of your medication.

Throw away any somatropin left over after the expiration date on the label has passed.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Call your doctor if you miss more than 3 doses in a row.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause tremors or shaking, cold sweats, increased hunger, headache, drowsiness, weakness, dizziness, fast heartbeat, and nausea. Long-term overdose may cause excessive growth.

What should I avoid while using Nutropin AQ (somatropin)?

If you use Zorbtive to treat short bowel syndrome, avoid drinking fruit juices or soda beverages. Follow the instructions of your doctor or nutrition counselor about what types of liquids you should drink while using Zorbtive.

Avoid drinking alcohol if you have short bowel syndrome. Alcohol can irritate your stomach and could make your condition worse.

Nutropin AQ (somatropin) side effects

If you have Prader-Willi syndrome, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring. Rare cases of serious breathing problems have occurred in patients with Prader-Willi syndrome who use somatropin.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

  
  


• 
  

  increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss;

  
  


• 
  

  sudden and severe pain behind your eyes, vision changes;

  
  


• 
  

  swelling in your head, face, hands, or feet; or

  
  


• 
  

  numbness or tingling in your wrist, hand, or fingers.

  
  

Less serious side effects may include:

• 
  

  headache, feeling tired;

  
  


• 
  

  redness, soreness, swelling, rash, itching, pain, or bruising where the medicine was injected;

  
  


• 
  

  pain in your arms or legs, joint stiffness or pain;

  
  


• 
  

  muscle pain; or

  
  


• 
  

  cold symptoms such as stuffy nose, sneezing, sore throat.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Nutropin AQ (somatropin)?

Before using somatropin, tell your doctor if you use insulin or take oral (by mouth) medicine to treat diabetes. Somatropin may affect blood sugar levels and you may need to adjust your dose of the diabetes medication. Do not change the dose of your diabetes medication without your doctor's advice.

Tell your doctor if you use any type of steroid medicine such as cortisone, dexamethasone, methylprednisolone, prednisone, and others. Steroids can make somatropin less effective and your doses may need to be adjusted. Do not stop using a steroid suddenly. Follow your doctor's instructions.

Tell your doctor about all other medications you use, especially cyclosporine (Gengraf, Neoral, Sandimmune), seizure medication, birth control pills, anabolic steroids, or hormone replacement medications for men or women.

This list is not complete and other drugs may interact with somatropin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Nutropin AQ resources

• Nutropin AQ Side Effects (in more detail)
• Nutropin AQ Use in Pregnancy & Breastfeeding
• Nutropin AQ Drug Interactions
• Nutropin AQ Support Group
• 0 Reviews for Nutropin AQ - Add your own review/rating

• Nutropin AQ MedFacts Consumer Leaflet (Wolters Kluwer)


• Nutropin AQ Prescribing Information (FDA)


• Somatropin Professional Patient Advice (Wolters Kluwer)


• Genotropin Prescribing Information (FDA)


• Genotropin Advanced Consumer (Micromedex) - Includes Dosage Information


• Genotropin MedFacts Consumer Leaflet (Wolters Kluwer)


• Humatrope Prescribing Information (FDA)


• Humatrope Cartridge MedFacts Consumer Leaflet (Wolters Kluwer)


• Norditropin MedFacts Consumer Leaflet (Wolters Kluwer)


• Norditropin Prescribing Information (FDA)


• Nutropin Prescribing Information (FDA)


• Nutropin MedFacts Consumer Leaflet (Wolters Kluwer)


• Nutropin Aq Subcutaneous, Injection Advanced Consumer (Micromedex) - Includes Dosage Information


• Nutropin Depot Prescribing Information (FDA)


• Omnitrope Prescribing Information (FDA)


• Omnitrope Consumer Overview


• Omnitrope MedFacts Consumer Leaflet (Wolters Kluwer)


• Saizen MedFacts Consumer Leaflet (Wolters Kluwer)


• Saizen Prescribing Information (FDA)


• Serostim MedFacts Consumer Leaflet (Wolters Kluwer)


• Serostim Prescribing Information (FDA)


• Tev-Tropin MedFacts Consumer Leaflet (Wolters Kluwer)


• Tev-Tropin Prescribing Information (FDA)


• Zorbtive Prescribing Information (FDA)


• Zorbtive MedFacts Consumer Leaflet (Wolters Kluwer)


• Zorbtive Consumer Overview

Compare Nutropin AQ with other medications

• Adult Human Growth Hormone Deficiency
• Growth Retardation, Chronic Renal Failure
• Hypopituitarism
• Idiopathic Short Stature
• Pediatric Growth Hormone Deficiency
• Short Stature for Age
• Turner's Syndrome

Where can I get more information?

• Your pharmacist can provide more information about somatropin.

See also: Nutropin AQ side effects (in more detail)